Fig. 1
From: PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
Allele matching for polygenic risk scores (PRS) between discovery and target data. The effect alleles and their reverse complements are indicated in red. Matching the effect alleles from the discovery data with the reported alleles in the target data is straightforward when SNPs are not strand-ambiguous (top and middle panel). The allele in the target data can be misassigned for strand-ambiguous SNPs (bottom)