Fig. 5
From: PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
A PRS for major depressive disorder (MDD) predicts symptoms of depression. Bar plots show the proportion of variance explained by PRS for MDD in the prediction of symptoms of depression. PRS were calculated across three datasets including or excluding strand-ambiguous SNPs at a range of p-value thresholds (PT = 0.1, 0.2, 0.3, 0.4, and 0.5). *p < 0.05, **p < 0.01, ***p < 0.001. Imputed PP = imputed posterior probabilities, Imputed HC = imputed posterior probabilities converted to “hard calls”, Array Data = observed genotypes