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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Arena-Idb: a platform to build human non-coding RNA interaction networks

Fig. 5

Arena-Idb integration process: identity by aliases, example 3 The Figure reports an example of integration of a ncRNA and a protein into a partial state of Arena-Idb. The ncRNA is labelled with two identifiers, a symbol and an Ensembl ID, and the protein is labelled only with a symbol. A interaction between the two objects is reported. In this case, two ncRNAs are already present in the partial knowledge. They are alternative transcripts of the HOTAIR gene, thus they are labelled with the symbol HOTAIR. However, the two ncRNAs can be distinguished by the specific Ensembl identifier linked with them. The integration procedure recognizes the identity of the input ncRNA with one of the two already present in the partial state by means of the Ensembl identifier. On the contrary, the input protein is directly mapped to a protein already in the partial state since no alias ambiguity arises. Finally, the biological interaction is flushed to the final knowledge base

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