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Fig. 7 | BMC Bioinformatics

Fig. 7

From: A novel computational method for automatic segmentation, quantification and comparative analysis of immunohistochemically labeled tissue sections

Fig. 7

Computation of the mean-distance histograms. a, d human tonsil sections marked with a Ki-67 antibody, and d Filagrin antibody (both the antibodies are marked with red stains). b, e segmented markers. c, f purple lines showing the manually signed borders of the basement membranes. The gray band shows the border neighborhood considered during the histogram computation; precisely, only markers in the gray band are used to compute the normalized mean-distance histograms plotted in (g). The histograms (computed over all the human tonsil dataset) clearly show that the Ki-67 antibody tend to be nearer to the border than the Filagrin one. In this case, the average intersection measure equals 0.60

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BMC Bioinformatics

ISSN: 1471-2105

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