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Table 3 Validation results for the model scenarios with restrictions to the number of selected variables

From: Priority-Lasso: a simple hierarchical approach to the prediction of clinical outcome using multi-omics data

 

pl1A

pl1B

Lasso1

pl2A

pl2B

Lasso2

ELN2017

TPR

0.672

0.672

0.651

0.640

0.658

0.643

0.556

TNR

0.667

0.658

0.661

0.647

0.664

0.653

0.723

AUC

0.711

0.731

0.726

0.713

0.727

0.725

0.663

C Uno

0.653

0.660

0.658

0.658

0.664

0.656

0.619

IBS2

0.175

0.172

0.176

0.175

0.172

0.177

0.181

IBS 4.4

0.197

0.192

0.191

0.197

0.191

0.193

0.204

Optimism

0.393

0.289

0.920

0.377

0.243

0.984

 

CI\(^{L}_{lower}\)

0.339

0.304

0.247

0.387

0.327

0.177

0.418

HR L

0.536

0.455

0.363

0.605

0.566

0.286

0.669

CI\(^{L}_{upper}\)

0.849

0.652

0.535

0.946

0.981

0.461

1.074

CI\(^{H}_{lower}\)

1.175

1.098

0.948

1.515

1.534

0.974

1.314

HR H

1.751

1.651

1.385

2.208

2.199

1.386

1.954

CI\(^{H}_{upper}\)

2.612

2.483

2.022

3.216

3.151

1.972

2.907

p-value LR

1.11e-08

1.05e-8

2.22e-10

1.07e-08

1.74e-08

4.99e-11

1.36e-07

  1. The acronyms in the first column are: TPR: True positive rate; TNR: True negative rate; AUC: Area under the curve, C Uno: Uno’s C-index, IBS2: Integrated Brier score up to 2 years, IBS 4.4: Integrated Brier score up to 4.4 years, Optimism: difference between calibration slopes of training and validation data, CI\(^{L}_{lower}\): lower bound of the 95% confidence interval for the hazard ratio of the low risk group, HR L: hazard ratio of the low risk group, CI\(^{L}_{upper}\): upper bound of the 95% confidence interval for the hazard ratio of the low risk group, CI\(^{H}_{lower}\): lower bound of the 95% confidence interval for the hazard ratio of the high risk group, HR H: hazard ratio of the high risk group, CI\(^{H}_{upper}\): upper bound of the 95% confidence interval for the hazard ratio of the high risk group, p-value: p-value of the likelihood ratio test