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Table 6 The 17 target metabolites that were producible by all FastPros, IdealKnock and GridProd

From: Grid-based computational methods for the design of constraint-based parsimonious chemical reaction networks to simulate metabolite production: GridProd

Target

FastPros

IdealKnock

GridProd

Common reactions

12ppd__R_c

3

42

1967

PFL

5dglcn_c

9

14

1960

AKGDH,IDOND/

    

IDOND2,THD2pp

ala__D_c

1

5

1953

DALAt2pp

cgly_c

5

6

1961

GLYAT, GLYCL

cytd_c

3

25

1966

None

glyc_c

5

18

1971

ALCD2x,EDD,

    

F6PA,MGSA

gthrd_c

4

7

1962

GART,GLYAT,

    

GLYCL,GTHRDHpp

gua_c

8

94

1964

GUAD,NTD10/

    

NTD11/NTD4/NTD7

his__L_c

5

41

1970

NTD1/NTD5

indole_c

8

14

1964

F6PA, MGSA, PYK

kdo2lipid4_c

1

2

1974

RPI

lac__D_c

3

29

1972

None

pyr_c

3

14

1962

None

succ_c

3

21

1970

None

thymd_c

4

36

1965

None

tyr__L_c

3

22

1962

None

uri_c

5

39

1965

None

  1. The number of knocked out (not used) reactions for each metabolite by each method and the common knocked out reactions are represented. “A/B” means that A or B is necessary to be knocked out