Fig. 5
From: XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data
Performance of XenofilteR and Xenome on PDX samples. a: Mutation calling on exome sequence data of a breast cancer PDX sample. The variant allele frequency (VAF) was plotted after filtering with XenofilteR (x-axis) and Xenome (y-axis). Plotted in black are mutations also detected in the patient sample, in green known SNPs and in red SNVs detected in the PDX only. b: Read count of each SNV used to calculate the VAF from A for Xenome and XenofilteR. c: Mutation calling on targeted sequencing of melanoma samples. In green all known SNPs are indicated, in black the remaining SNVs. d: Validation of the SNP rs7121 (GNAS) by Sanger sequencing with human-specific primers