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Table 1 Number of test data points that are significant (FDR < 0.05) according to various strategies for controlling the FDR. “Control data” indicates the control data-based local FDR strategy described in the present work. All other strategies indicate the assumed parametric form for the null distribution whose parameters are estimated via Efron’s semi-parametric local FDR method. Results are shown for a representative individual

From: Using controls to limit false discovery in the era of big data

null distribution form

number of significant calls

control data

47

lognormal

106

2-mix

118

3-mix

119

4-mix

123

normal

106