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Fig. 2 | BMC Bioinformatics

Fig. 2

From: ECPred: a tool for the prediction of the enzymatic functions of protein sequences based on the EC nomenclature

Fig. 2

Flowchart of ECPred together with the prediction route of an example query protein. Query protein (PQ) received a score that is higher than the class specific positive cut-off value of main EC class 1.-.-.- (i.e., oxidoreductase) at Level 0–1 classification (Sm1 > Sc1); as a result, the query is only directed to the models for the subclasses of main class 1.-.-.-. Considering the subclass prediction (Level 2), PQ received a high score (Ss1.1 > Sc1.1) for EC 1.1.-.- (i.e., acting on the CH-OH group of donors) and further directed to the children sub-subclass EC numbers, where it received a high score (Sss1.1.2 > Sc1.1.2) for EC 1.1.2.- (i.e., with a cytochrome as acceptor) at Level 3, and another high score (Su1.1.2.4 > Sc1.1.2.4) for EC 1.1.2.4 (i.e., D-lactate dehydrogenase - cytochrome) at the substrate level (Level 4) and received the final prediction of EC 1.1.2.4

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