Fig. 4

TF peaks farther from TSS are more cell type-specific than peaks overlapping a TSS. a-d Correlation heatmaps of TF ChIP-seq experiments in human (A and B) or mouse (C and D) datasets from only the peaks at less than 1 kb from the nearest TSS (A and C) or from only the peaks at 10 kb or more of the nearest TSS (upstream or downstream). Colour side bars indicate the cell of origin of the ChIP-seq experiments. Only experiments performed in cell types with more than 30 ChIP-seq experiments are shown. e and f K-means clustering of highly-bound regions in human e and mouse f. TF density: proportion of ChIP-seq experiment with a peak at a given location. Top colour bars: proportion of peaks upstream (blue), at (white), or downstream of (red) the nearest TSS. Very highly bound regions in all cells tend to mostly overlap a TSS. Cell specific highly bound regions tends to be more distal. A large lowly TF-bound cluster of genomic regions was removed from the figure for clarity in both human and mouse