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Table 5 Top 10 Significant Pairs for Degressive DDIs

From: TMFUF: a triple matrix factorization-based unified framework for predicting comprehensive drug-drug interactions of new drugs

Rank

Side Effect 1

Side Effect 2

1

‘accelerated hypertension’

‘hypotonia’

2

‘burning sensation mucosal’

‘overdose’

3

‘accelerated hypertension’

‘overdose’

4

‘accelerated hypertension’

‘convulsion’

5

‘accelerated hypertension’

‘diabetes mellitus inadequate control’

6

‘accelerated hypertension’

‘neuroleptic malignant syndrome’

7

‘accelerated hypertension’

‘dependence’

8

‘accelerated hypertension’

‘cholecystitis chronic’

9

‘gastrointestinal disorder’

‘overdose’

10

‘abuse’

‘accelerated hypertension’