Table 6 Selected examples of new one-to-one MF GO-Pfam associations
From: Computational discovery of direct associations between GO terms and protein domains
MF GO ID | MF GO term | Pfam ID | Pfam description | Consensus Score | Class |
|---|---|---|---|---|---|
Case (i) : Trivial but not in InterPro | |||||
GO:0008437 | thyrotropin-releasing hormone activity | PF05438 | Thyrotropin-releasing hormone (TRH) | 0.0638 | gold |
Case (ii) MF GO term more specific than Pfam description | |||||
GO:0098640 | integrin binding involved in cell-matrix adhesion | PF09085 | Adhesion molecule, immunoglobulin-like | 0.0752 | gold |
Case (iii) Pfam description more specific than MF GO term | |||||
GO:1990919 | nuclear membrane proteasome anchor | PF08559 | Cut8, nuclear proteasome tether protein | 0.0309 | gold |
Case (iv) MF GO term and Pfam description differ | |||||
GO:0047991 | hydroxylamine oxidase activity | PF13447 | Seven times multi-haem cytochrome CxxCH | 0.2654 | gold |
Case (v) Domains of yet unknown function | |||||
GO:1990838 | poly(U)-specific exoribonuclease, activity producing 3’ uridine cyclic phosphate ends | PF09749 | Uncharacterised conserved protein | 0.0235 | gold |
GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyl transferase activity | PF15027 | Domain of unknown function (DUF4525) | 0.5273 | silver |
GO:0030735 | carnosine N-methyltransferase activity | PF07942 | N2227-like protein | 0.2705 | silver |
GO:0010340 | carboxyl-O-methyltransferase activity | PF04301 | Protein of unknown function (DUF452) | 0.0201 | silver |
GO:0016772 | transferase activity, transferring phosphorus-containing groups | PF01989 | Protein of unknown function DUF126 | 0.0137 | silver |
GO:0071617 | lysophospholipid acyltransferase activity | PF10998 | Protein of unknown function (DUF2838) | 0.0072 | silver |
GO:0015666 | restriction endodeoxyribonuclease activity | PF12102 | Domain of unknown function (DUF3578) | 0.0111 | bronze |
GO:0016841 | ammonia-lyase activity | PF11807 | Domain of unknown function (DUF3328) | 0.0066 | bronze |