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Fig. 4 | BMC Bioinformatics

Fig. 4

From: The poly-omics of ageing through individual-based metabolic modelling

Fig. 4

Principal component analysis applied to pathways. The correlation plots of fluxes are shown for the pathways with the top-20 overall difference in each group, 21- and 22-49, 21- and 50 +, and 22-49 and 50 + (a, b, c). The plots show the large amount of intercorrelation between pathways. A biplot of individuals grouped by age and the top 10 pathways contributing to overall variance of components 1 and 2 is also shown d. We note some differentiation between the three age groups, with the biggest differentiation shown in the axis of the 50 + group compared to the other two. The 50 + group appears to lie along the glyoxylate and dicarboxylate metabolism axis

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