Table 1 Examples of known GPCR-endogenous ligand pairs with matching disease indications and corresponding Open Targets overall scores
From: Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands
Disease | GPCR Name | Score | Endogenous ligand Name | Score |
|---|---|---|---|---|
Epilepsy | GALR2 | 0.02 | GAL | 1.00 |
Obesity | MC1R | 0.04 | POMC | 1.00 |
Alzheimer’s disease | FPR2 | 0.04 | APP | 1.00 |
Inflammatory bowel disease | CCR3 | 0.05 | CCL7 | 0.87 |
Hypertension | AGTR2 | 0.15 | AGT | 1.00 |
Rheumatoid arthritis | CCR6 | 0.99 | CCL20 | 0.06 |
Macular degeneration | CX3CR1 | 1.00 | CX3CL1 | 0.05 |
Biliary dyskinesia | SCTR | 1.00 | VIP | 0.02 |
osteoporosis | CALCR | 1.00 | ADM | 0.04 |
vascular disease | EDNRA | 1.00 | EDN2 | 0.04 |