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Table 1 Examples of known GPCR-endogenous ligand pairs with matching disease indications and corresponding Open Targets overall scores

From: Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

Disease GPCR
Name
Score Endogenous ligand
Name
Score
Epilepsy GALR2 0.02 GAL 1.00
Obesity MC1R 0.04 POMC 1.00
Alzheimer’s disease FPR2 0.04 APP 1.00
Inflammatory bowel disease CCR3 0.05 CCL7 0.87
Hypertension AGTR2 0.15 AGT 1.00
Rheumatoid arthritis CCR6 0.99 CCL20 0.06
Macular degeneration CX3CR1 1.00 CX3CL1 0.05
Biliary dyskinesia SCTR 1.00 VIP 0.02
osteoporosis CALCR 1.00 ADM 0.04
vascular disease EDNRA 1.00 EDN2 0.04