Table 2 Example Observations from AgeFactDB
From: 3D Network exploration and visualisation for lifespan data
Free-text Ageing Phenotype Observation (Data Type 1) – OB_006092 | |
Species | Mus musculus |
Gene Symbol | Trp63 |
NCBI Gene ID | 22061 |
Other Ageing Factor Name | - |
Description | Heterozygous mice have a shortened lifespan and display features of accelerated ageing. |
PubMed | 16107615 |
Source | GenAge |
Observation Stable ID | OB_006092 |
Structured LO (Data Type 2) – OB_000094 | |
Species | Saccharomyces cerevisiae |
Strain | BY4742 |
Gene | FOB1 (NCBI Gene ID 851688) - allele type: deletion/null; |
SIR2 (NCBI Gene ID 851520) - allele type: deletion/null; | |
TOR1 (NCBI Gene ID 853529) - allele type: deletion/null; | |
Compound | - |
Other Ageing Factor | - |
Significant Lifespan Effect | increased |
Change | 33.47% |
Observed Lifespan | 32.7 |
Reference Lifespan | 24.5 |
Lifespan Unit | divisions |
Measure | mean |
Temperature | 30 |
Temperature Unit | °C |
Sex/Mating Type | matalpha |
Description | Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [PubMed ID 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [PubMed ID 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Source | Lifespan Observations Database (ID: 1093) |
Observation Stable ID | OB_000094 |
Homology Analysis Observation – OB_008235 | |
Number of Experimentally Confirmed Ageing-related Genes in Homology Group | 1 |
Description | The HomoloGene homology group 38185 contains 1 gene with experimental evidence for ageing relevance (C48E7.2 - Caenorhabditis elegans) and 12 other genes. |
Homologs | POU1F1 Gallus gallus (NCBI Gene ID 374215); |
POU1F1 Canis lupus familiaris (NCBI Gene ID 403753); | |
POU1F1 Pan troglodytes (NCBI Gene ID 470861); | |
POU1F1 Bos taurus (NCBI Gene ID 282315); | |
POU1F1 Macaca mulatta (NCBI Gene ID 719349); | |
Pou1f1 Mus musculus (NCBI Gene ID 18736); | |
Pou1f1 Rattus norvegicus (NCBI Gene ID 25517); | |
pou1f1 Danio rerio (NCBI Gene ID 405777); | |
POU1F1 Homo sapiens (NCBI Gene ID 5449) | |
Observation Stable ID | OB_008235 |
Source | AgeFactDB Homology Analysis |
Homology Source | HomoloGene homology group 38185 |