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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Discovering the ‘Dark matters’ in expression data of miRNA based on the miRNA-mRNA and miRNA-lncRNA networks

Fig. 1

Flowchart for constructing an individual specific miRNA-mRNA network (ISMMN) and an individual specific miRNA-lncRNA network (ISMLN) for a single cancer sample. a The n normal samples are selected as the reference samples, and a reference miRNA-mRNA network (RMMN) and a reference miRNA-lncRNA network (RMLN) are constructed using Pearson Correlation Coefficients (PCC) based on the 155,044 miRNA-mRNA and 155,653 interactions. b The sample Sn + 1 is added to the above reference samples, and a perturbed miRNA-mRNA network (PMMN) and a perturbed miRNA-mRNA network (PMLN) are built by recalculating the PPC. Finally, we define the difference (PMMN-RMMN) and (PMLN-RMLN) as the ISMMN and ISMLNof sample Sn + 1

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BMC Bioinformatics

ISSN: 1471-2105

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