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Table 1 Optimal evolutionary models of DNA methylation and gene expression for the four gene families in controls (promoter methylation vs. gene expression gene body methylation vs. gene expression)

From: Multi–omic analysis of signalling factors in inflammatory comorbidities

Disease Chemokine receptor TNF receptor TGF– β IL17
Allergy OUOU OUOU OUOU OUOU OUOU OUOU OUOU OUOU
Asthma OUOU OUOU OUOU OUOU OUOU OUOU OUOU OUOU
CFS OUOU OUOU OUOU OUOU OUOU OUOU OUOU OUOU
Colitis BM BM OUOU OUOU OUOU OUOU OUOU OUOU
Colon Cancer OUOU OUOU OUOU BM OUOU OUOU OUOU OUOU
Crohn OUOU OUOU BM OUOU OUOU OUOU OUOU OUOU
RA OUBM OUOU OUOU OUOU OUOU OUOU BM OUOU
SLE OUOU OUOU OUOU OUOU OUOU OUOU OUOU OUOU
T2D OUOU OUOU OUOU OUOU OUOU OUOU BM BM
  1. OUOU: bivariate OU model, both methylation and expression follow OU model; BM: Brownian Motion model, both methylation and expression follow BM model; OUBM: methylation and expression follow different models