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Table 2 Significant disease associated genes in the chemokine receptor family

From: Multi–omic analysis of signalling factors in inflammatory comorbidities

Disease Up–regulated DEG Down–regulated DEG Up–regulated DMG Down–regulated DMG
Allergy CCR6, CCR7 CXCR4
Asthma CXCR7
CFS CXCR4, CX3CR1
Colitis CXCR4 XCR1, CCRL1 CCR4 CCR7,CMKLR1
Colon Cancer
Crohn
RA CXCR1, CXCR2, CXCR4
SLE CCR5, CMKLR1, CXCR2, CXCR4, CX3CR1, CCR1 XCR1
T2D CXCR4 CXCR4
  1. DEG stands for dysregulated expressed genes and DMG stands for dysregulated methylated genes. Genes in bold represent significant dysregulations according to both promoter methylation model and gene body methylation model; Genes in italic represent significant dysregulations according to promoter methylation model; Genes in normal fonts represent significant dysregulations according to gene body methylation model