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Table 3 Significant disease associated genes in the TNF receptor family

From: Multi–omic analysis of signalling factors in inflammatory comorbidities

Disease Up–regulated DEG Down–regulated DEG Up–regulated DMG Down–regulated DMG
Allergy TNFRSF4
Asthma TNFRSF21
CFS TNFRSF1A, CD27, TNFRSF1B TNFRSF11B TNFRSF4
Colitis TNFRSF14, CD27, TNFRSF1B
Colon Cancer RELT, TNFRSF4, TNFRSF13B TNFRSF12A
Crohn TNFRSF14, TNFSRF1B
RA RELT, TNFSRF4, TNFRSF17, TNFRSF13B, EDA2R, EDAR
SLE TNFRSF1B TNFRSF4, EDA2R
T2D TNFRSF21, TNFRSF12A TNFRSF17
  1. DEG stands for dysregulated expressed genes and DMG stands for dysregulated methylated genes. Genes in bold represent significant dysregulations according to both promoter methylation model and gene body methylation model; Genes in italic represent significant dysregulations according to promoter methylation model; Genes in normal fonts represent significant dysregulations according to gene body methylation model