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Table 4 Significant disease associated genes in the TGF– β family

From: Multi–omic analysis of signalling factors in inflammatory comorbidities

Disease Up–regulated DEG Down–regulated DEG Up–regulated DMG Down–regulated DMG
Allergy GDF11, LEFTY2, TGFB3 GDF3, GDF15
Asthma GDF2, GDF15, MSTN, INHBA, INHBB, INHBC BMP4 GDF2, GDF9, BMP15, MSTN, PSPN
CFS
Colitis TGFB1, TGFB3, BMP15, INHBC, GDF9 GDF15
Colon Cancer PSPN
Crohn TGFB1, TGFB3, BMP15, INHBC GDF15
RA GDF11, GDF15, INHBA, BMP6 GDF10, TGFB2, GDF3, ARTN, BMP4, GDF7, BMP5, INHBC, INHA LEFTY2, TGFB3 GDF1
SLE BMP15, GDF9 GDF3, GDF15
T2D GDF15, INHBA MSTN PSPN ARTN, INHBE
  1. DEG stands for dysregulated expressed genes and DMG stands for dysregulated methylated genes. Genes in bold represent significant dysregulations according to both promoter methylation model and gene body methylation model; Genes in italic represent significant dysregulations according to promoter methylation model; Genes in normal fonts represent significant dysregulations according to gene body methylation model