Table 6 Literature evidence for the identified disease associated genes in the four signalling gene families
From: Multi–omic analysis of signalling factors in inflammatory comorbidities
Disease | Disease genes with evidence |
|---|---|
Allergy | |
Asthma | CXCR7 [73] |
CFS | |
Colitis | TGFB1 [76]; TGFB3 [77]; XCR1 [78]; CCR4 [79]; CKMLR1 [80]; CXCR2 [81]; CXCR4 [82]; CD27 [83]; CCR7 [83]; TNFRSF1B [84] |
Crohn | GDF15 [85]; TNFRSF1B [86]; INHBC [87]; TGFB3 [77]; IL17E [88]; TGFB1 [76] |
RA | GDF15 [89]; GDF1 [90]; GDF11 [91]; EDAR [92]; CXCR1 [93]; Relt [94]; TNFRSF13b [95]; TGFB2 [96]; TGFB3 [97]; CXCR2 [98]; BMP4 [99]; BMP5 [99]; BMP6 [100]; INHBA [101] |
SLE | |
T2D | GDF15 [104]; IL17A [105, 106]; IL17F [107]; ARTN [62]; INHBA [108]; CXCR4 [109, 110]; TNFSR17 [111]; TNFSR14 [112]; MSTN [113]; BMP4 [114]; TNFRSF21 [115]; TNFRSF12A [116] |