Fig. 3

Schematic showing the study design. [To demonstrate the assembly gap bias if not accounted for in the statistical testing, we used two null model definitions that only differed in whether or not they avoided assembly gaps. For the pairwise colocalization analysis, we deliberately used a combination of real and synthetic track pairs to nullify any true biological association between them. The synthetic tracks were generated in such a way that they mimick the real tracks in terms of the genomic distributional properties as shown in the ellipse. The distributions of p-values, observed colocalization measures, average colocalization measures under the null models were examined to see if or not there is a bias.]