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Table 1 Image measurements used in this study

From: RefCell: multi-dimensional analysis of image-based high-throughput screens based on ‘typical cells’

 

Name of measurement

Description

Nuclear shape

Area

Area of nucleus

Circularity

Ratio of perimeter to area, normalized so that a circle would have ratio 1

Eccentricity

Eccentricity of nucleus

Invaginations

Number of invaginations along nuclear boundary

Major Axis Length

Major axis length of the best fit ellipse to nuclear boundary

Mean Curvature

Mean curvature along nuclear boundary

Mean Negative Curvature

Average of only negative curvatures along nuclear boundary

Minor Axis Length

Minor axis length of the best fit ellipse

Perimeter

Perimeter of nucleus

Solidity

Percentage of pixels inside the convex hull that are inside the boundary

Std of Curvature

Standard deviation of curvature

Tortuosity

Tortuosity of nuclear boundary

Intensity

BP Intensity

Mean intensity of points along nuclear boundary

Mean Intensity

Mean intensity inside nucleus

Std of Intensity

Standard deviation of intensity inside nucleus