From: RefCell: multi-dimensional analysis of image-based high-throughput screens based on ‘typical cells’
Name of measurement | Description | |
---|---|---|
Nuclear shape | Area | Area of nucleus |
Circularity | Ratio of perimeter to area, normalized so that a circle would have ratio 1 | |
Eccentricity | Eccentricity of nucleus | |
Invaginations | Number of invaginations along nuclear boundary | |
Major Axis Length | Major axis length of the best fit ellipse to nuclear boundary | |
Mean Curvature | Mean curvature along nuclear boundary | |
Mean Negative Curvature | Average of only negative curvatures along nuclear boundary | |
Minor Axis Length | Minor axis length of the best fit ellipse | |
Perimeter | Perimeter of nucleus | |
Solidity | Percentage of pixels inside the convex hull that are inside the boundary | |
Std of Curvature | Standard deviation of curvature | |
Tortuosity | Tortuosity of nuclear boundary | |
Intensity | BP Intensity | Mean intensity of points along nuclear boundary |
Mean Intensity | Mean intensity inside nucleus | |
Std of Intensity | Standard deviation of intensity inside nucleus |