Table 10 Gene characteristics significant in stepwise best subset multiple linear regression model for missense, nonsense, and frameshift mutations analyzed together
From: Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples
Predictor | T-test | P-value | Beta (ß) |
|---|---|---|---|
Number of silent mutations in the gene | 121.8 | 1.6x− 789 | 0.72 |
Gene size in nucleotides | 41.6 | 1.4x− 220 | 0.23 |
Nucleotide diversity | −8.5 | 3.3x−17 | −0.04 |
Relative replication time | −7.0 | 1.7x−12 | −0.03 |
Percentage of “G” | − 7.0 | 2.6x− 12 | − 0.04 |
Percentage of “C” | − 7.0 | 3.1x− 12 | − 0.05 |
“reptime” from MutsigCV | 5.4 | 4.1x− 8 | 0.03 |
Percentage of “CpG” | −3.7 | 1.0x− 4 | − 0.02 |
Evolutionary conservation | − 3.3 | 4.7x− 4 | − 0.01 |
Percentage of “A” | 2.6 | 4.8x− 3 | 0.02 |
“expr” from MutsigCV | 2.5 | 6.4x− 3 | 0.01 |