Table 6 Gene characteristics selected for the model building for the missense, nonsense, and frameshift mutations

Density of SNPS (1 K Genomes Project)

yes

no

yes

Evolutionary conservation

yes

yes

no

Gene expression in CCLE cancer cell lines^a

yes

yes

no

Gene size in nucleotides

yes

yes

yes

Nucleotide diversity

yes

yes

yes

Number of potential substitution sites

yes

yes

yes

Number of silent mutations in the gene

yes

yes

yes

Percentage of “A”

no

yes

yes

Percentage of “C”

yes

yes

no

Percentage of “G”

yes

yes

yes

Percentage of “T”

yes

yes

no

Percentage of “CpGs”

yes

yes

yes

Replication time

yes

yes

no

Chromatin accessibility

yes

yes

no