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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Degeneracy and genetic assimilation in RNA evolution

Fig. 6

Frequency distribution of evolvability of inverse folds of Phenylalanine. 105 inverse folds were obtained using a neutral walk. Among these sequences, 26491 were degenerate. The x-axis (scaled logarithmically) shows the total number of structures to which the one point mutants of a sequence fold. The blue bars depict the distribution for all the 105 inverse folds and the yellow bars show the degenerate sequences. We observe that as degenerate sequences lie at the intersection of two (ore more) quasineutral networks, they tend to have higher evolvabilities: the mean evolvability of all the inverse folds is 111 while that of degenerate inverse folds is 143. Additionally most high-evolvability sequences are degenerate. The highest evolvability for our sample was 495. The inset shows the distribution of single-MFE evolvability, see Methods for details

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