TY - JOUR AU - Zhang, Long AU - Yu, Guoxian AU - Guo, Maozu AU - Wang, Jun PY - 2018 DA - 2018/12/31 TI - Predicting protein-protein interactions using high-quality non-interacting pairs JO - BMC Bioinformatics SP - 525 VL - 19 IS - 19 AB - Identifying protein-protein interactions (PPIs) is of paramount importance for understanding cellular processes. Machine learning-based approaches have been developed to predict PPIs, but the effectiveness of these approaches is unsatisfactory. One major reason is that they randomly choose non-interacting protein pairs (negative samples) or heuristically select non-interacting pairs with low quality. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-018-2525-3 DO - 10.1186/s12859-018-2525-3 ID - Zhang2018 ER -