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Table 8 Results based on different negative datasets on S. cerevisiae, H. sapiens and M. musculus

From: Predicting protein-protein interactions using high-quality non-interacting pairs

Species Negative samples ACC PE RE SPE MCC F 1 AUC
S. cerevisiae NIP-SS 94.34% ± 0.38% 95.62% ± 0.75% 92.96% ± 0.40% 95.74% ± 0.75% 88.73% ± 0.77% 94.27% ± 0.34% 98.24% ± 0.11%
  NIP-RW 87.92% ± 0.24% 90.04% ± 1.69% 85.32% ± 1.90% 90.48% ± 2.20% 75.97% ± 0.55% 87.59% ± 0.35% 94.23% ± 0.12%
  Sub 93.79% ± 0.43% 95.18% ± 0.41% 92.25% ± 0.78% 95.33% ± 0.45% 87.62% ± 0.83% 93.69% ± 0.38% 98.13% ± 0.17%
  Random method 74.20% ± 0.78% 72.68% ± 1.45% 77.59% ± 0.89% 70.83% ± 1.77% 48.53% ± 1.47% 75.04% ± 0.76% 81.29% ± 0.34%
H. sapiens NIP-SS 86.17% ± 0.93% 86.38% ± 1.27% 85.88% ± 1.55% 86.48% ± 1.00% 72.36% ± 1.85% 86.12% ± 1.05% 92.20% ± 0.82%
  NIP-RW 86.44% ± 0.59% 90.05% ± 0.48% 81.87% ± 2.35% 90.91% ± 1.09% 73.14% ± 1.12% 85.75% ± 1.28% 92.30% ± 0.70%
  Sub 93.34% ± 0.58% 93.19% ± 0.42% 93.51% ± 0.94% 93.17% ± 0.37% 86.68% ± 1.16% 93.35% ± 0.57% 96.22% ± 0.45%
  Random method 60.46% ± 1.54% 60.07% ± 1.74% 62.33% ± 1.91% 58.50% ± 3.24% 20.85% ± 3.14% 61.17% ± 1.63% 64.57% ± 1.35%
M. musculus NIP-SS 81.69% ± 1.48% 80.57% ± 2.20% 83.73% ± 2.97% 79.51% ± 4.47% 63.44% ± 3.16% 82.06% ± 0.84% 87.04% ± 1.95%
  NIP-RW 80.66% ± 2.14% 84.89% ± 5.41% 74.83% ± 3.46% 86.72% ± 4.62% 61.97% ± 4.53% 79.41% ± 2.52% 87.75% ± 2.25%
  Sub 91.82% ± 1.26% 90.13% ± 2.57% 93.93% ± 2.38% 89.76% ± 2.41% 83.78% ± 2.40% 91.95% ± 1.44% 94.81% ± 0.74%
  Random method 50.76% ± 2.12% 50.80% ± 5.77% 52.17% ± 1.90% 49.44% ± 3.26% 1.60% ± 3.86% 51.37% ± 3.58% 51.40% ± 2.43%