Table 8 Results based on different negative datasets on S. cerevisiae, H. sapiens and M. musculus
From: Predicting protein-protein interactions using high-quality non-interacting pairs
Species | Negative samples | ACC | PE | RE | SPE | MCC | F 1 | AUC |
|---|---|---|---|---|---|---|---|---|
S. cerevisiae | NIP-SS | 94.34% ± 0.38% | 95.62% ± 0.75% | 92.96% ± 0.40% | 95.74% ± 0.75% | 88.73% ± 0.77% | 94.27% ± 0.34% | 98.24% ± 0.11% |
|  | NIP-RW | 87.92% ± 0.24% | 90.04% ± 1.69% | 85.32% ± 1.90% | 90.48% ± 2.20% | 75.97% ± 0.55% | 87.59% ± 0.35% | 94.23% ± 0.12% |
|  | Sub | 93.79% ± 0.43% | 95.18% ± 0.41% | 92.25% ± 0.78% | 95.33% ± 0.45% | 87.62% ± 0.83% | 93.69% ± 0.38% | 98.13% ± 0.17% |
|  | Random method | 74.20% ± 0.78% | 72.68% ± 1.45% | 77.59% ± 0.89% | 70.83% ± 1.77% | 48.53% ± 1.47% | 75.04% ± 0.76% | 81.29% ± 0.34% |
H. sapiens | NIP-SS | 86.17% ± 0.93% | 86.38% ± 1.27% | 85.88% ± 1.55% | 86.48% ± 1.00% | 72.36% ± 1.85% | 86.12% ± 1.05% | 92.20% ± 0.82% |
|  | NIP-RW | 86.44% ± 0.59% | 90.05% ± 0.48% | 81.87% ± 2.35% | 90.91% ± 1.09% | 73.14% ± 1.12% | 85.75% ± 1.28% | 92.30% ± 0.70% |
|  | Sub | 93.34% ± 0.58% | 93.19% ± 0.42% | 93.51% ± 0.94% | 93.17% ± 0.37% | 86.68% ± 1.16% | 93.35% ± 0.57% | 96.22% ± 0.45% |
|  | Random method | 60.46% ± 1.54% | 60.07% ± 1.74% | 62.33% ± 1.91% | 58.50% ± 3.24% | 20.85% ± 3.14% | 61.17% ± 1.63% | 64.57% ± 1.35% |
M. musculus | NIP-SS | 81.69% ± 1.48% | 80.57% ± 2.20% | 83.73% ± 2.97% | 79.51% ± 4.47% | 63.44% ± 3.16% | 82.06% ± 0.84% | 87.04% ± 1.95% |
|  | NIP-RW | 80.66% ± 2.14% | 84.89% ± 5.41% | 74.83% ± 3.46% | 86.72% ± 4.62% | 61.97% ± 4.53% | 79.41% ± 2.52% | 87.75% ± 2.25% |
|  | Sub | 91.82% ± 1.26% | 90.13% ± 2.57% | 93.93% ± 2.38% | 89.76% ± 2.41% | 83.78% ± 2.40% | 91.95% ± 1.44% | 94.81% ± 0.74% |
|  | Random method | 50.76% ± 2.12% | 50.80% ± 5.77% | 52.17% ± 1.90% | 49.44% ± 3.26% | 1.60% ± 3.86% | 51.37% ± 3.58% | 51.40% ± 2.43% |