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Table 7 Descriptors and regression coefficients of the best model for cyclic peptide drugs obtained by FBS trained on small molecule training data

From: Computational prediction of plasma protein binding of cyclic peptides from small molecule experimental data using sparse modeling techniques

Descriptor

Category

Regression coef.

PEOE8

Physical property

−0.42

PEOE9

Physical property

−0.39

Xu

Topological descriptors

0.75

Percent Human Oral Absorption

Physical property

0.18

QPLogPo/w

Physical property

0.36