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Fig. 1 | BMC Bioinformatics

Fig. 1

From: MicroRNA dysregulational synergistic network: discovering microRNA dysregulatory modules across subtypes in non-small cell lung cancers

Fig. 1

Overview of the MiRNA Dysregulational Synergism Network pipeline. In the first step, multiple differential analyses between different subtype groups identified miRNA-target dysregulations. Then, the miRNA dysregulations across multiple subtype analyses is used to form the miRNA-target dysregulation association matrix. Next, the MDSN network is constructed by computing miRNA-miRNA similarity measures, and is used to extract miRNA modules by a graph partitioning method. Finally, provided the extracted miRNA modules, the Sparse Group Lasso performs classification of the cancer stage given a sample’s miRNA expression profile

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BMC Bioinformatics

ISSN: 1471-2105

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