Fig. 4
From: CoMetGeNe: mining conserved neighborhood patterns in metabolic and genomic contexts
CoMetGeNe trail for E. coli in the glycine, serine, and threonine metabolism pathway. a Partial view of the glycine, serine, and threonine metabolism pathway, adapted from KEGG PATHWAY, map eco00260 (October 26, 2017 version). Reaction R02291 performing the enzymatic activity 1.2.1.11 was skipped (δD=1). Genes with black identifiers do not belong to the gene group in b. Genes with red identifiers are neighbors on the positive strand of the E. coli chromosome. See Fig. 3a for other explanations. b Group of homologous genes involved in the trail in a, present in various species. Eleven of the species in the dataset (highlighted in gray) either do not have functionally similar genes to b0003, or are not contiguous with genes functionally similar to b0002 and b0004. α-, β-, γ-, and δ-proteobacteria are highlighted in pink; Terrabacteria, in brown; Sphingobacteria (FCB bacteria), in yellow; and Planctobacteria (PVC bacteria), in light green. c Group of reactions defining the trail in a. The cells highlighted in gray correspond to the three species among the ones highlighted in gray in b that do not perform reaction R01771 (catalyzed by the product of gene b0003 in E. coli)