Fig. 2

Evaluation of the different similarity metrics for 352 well-annotated protein-coding genes (Test₃₅₂). For each gene in Test₃₅₂ all methods were applied for prediction of function, and similarity between real and predicted terms were measured with TopoICSim and GOSemSim. The table shows average similarity scores over the test set, with standard deviation. LncRNA2Function: Co-expressed protein-coding genes was obtained for each gene in Test₃₅₂ using [22] with Pearson correlation coefficient > 0.9. Co-LncRNA_Pearson or _Spearman: Co-expressed protein-coding genes was obtained for each gene in Test₃₅₂ using [24] with Pearson or Spearman correlation coefficient > 0.8 and LncRNA2Function expression data