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Fig. 1 | BMC Bioinformatics

Fig. 1

From: NCLcomparator: systematically post-screening non-co-linear transcripts (circular, trans-spliced, or fusion RNAs) identified from various detectors

Fig. 1

The NCLcomparator process. a Flowchart of NCLcomparator. b Examples of NCL events derived from ambiguous alignments with an alternative co-linear explanation (top) and multiple hits (bottom). For the top panel, the host gene (RP11-545 J16.1) includes two alternatively spliced transcripts (ENST00000540229.1 with 16 exons and ENST00000381541.7 with 14 exons). The concatenated sequence of the intragenic NCL event (E11-E7; ENST00000540229.1) has an alternative co-linear explanation (E11 of ENST00000540229.1 and E7 of ENST00000381541.7). For the bottom panel, the concatenated sequence of the intragenic NCL event (E4-E4; SCD) mapped to multiple positions (2 hits). c Schematic illustration of the NCL junction and the corresponding co-linear junctions at both NCL donor (D1 and D2) and acceptor (A1 and A2) sites. The mapped read spanning within (circRNA isoform) or outside (trans-spliced isoform) a detected intragenic circle is illustrated. E, exon. NNCL, number of reads spanning the NCL junction

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BMC Bioinformatics

ISSN: 1471-2105

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