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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico

Fig. 1

Type I error simulation results with MAF UB of 0.01. For visualization and comparison purposes, blue and red horizontal lines indicate type I error at 0.05 and 0.1 respectively. Fig. (a) shows the results for type I error for an equal number of cases and controls for differing sample sizes. Note that the y-axis only goes to a type I error rate of 0.1. Fig. (b) shows the type I error rate for different unbalanced cases and controls as arranged by case to control ratio. The axis is labeled by the number of cases then the number of controls for each simulation. The percentage of cases to controls is also listed below the number of cases and controls. Figs. (c and d) show the results as ordered by the number of cases. Figure 1c has 10,000 control and Fig. 1d has 30,000 control

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