Exploiting locational and topological overlap model to identify modules in protein interaction networks

BMC Bioinformatics

Table 1 Network reliability comparison

Network	Protein	Interaction	Avg No. of literature	Verified in vivo	Precision	Recall	MCC
HPRD
GPIN	8136	37,039	1.13	40.31%	0.8755	0.2058	0.2242
CLPIN	6882	23,135	1.23^a	54.83% ^a	0.9025	0.1900	0.2339
BioGRID
GPIN	12,289	268,684	1.14	–	0.7842	0.2347	0.1741
CLPIN	9749	94,780	1.27^a	–	0.8369	0.2211	0.2050

^aSignificant difference by RankSum test, p < 0.001. PIN Protein Interaction Network, CLPIN Co-Localization Protein Interaction Network. Avg No. of literature The average number of literature supported the interaction, Verified in vivo The percentage of protein interactions that have been verified in vivo in the HPRD database

ISSN: 1471-2105