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Table 1 Power (α=0.05) for the SKAT test under the population stratification scenario and varying levels of stratification. 10 causal variants were selected in causal genes. n2: number of individuals of African descent out of 2000 individuals

From: sim1000G: a user-friendly genetic variant simulator in R for unrelated individuals and family-based designs

OR

n2 = 0

100

200

400

Power (no covariate adjustment)

 1.5

65.95%

58.40%

50.80%

30.77%

 1.8

87.76%

83.35%

77.40%

54.17%

 3

99.32%

99.25%

98.69%

93.91%

 5

99.85%

99.90%

99.81%

99.40%

Power (with population as a covariate)

 1.5

 

64.29%

64.56%

62.52%

 1.8

 

87.35%

86.77%

85.10%

 3

 

99.27%

99.15%

99.25%

 5

 

99.83%

99.86%

99.90%