Skip to main content

Table 3 Statistical power comparison

From: sim1000G: a user-friendly genetic variant simulator in R for unrelated individuals and family-based designs

 

N_cases = N_controls = 250

N_cases = N_controls = 1000

Simulator

MAF range

SKAT

Burden

SKAT-O

SKAT

Burden

SKAT-O

sim1000G

n = 72

21.00%

19.00%

27.00%

70.00%

53.00%

76.00%

n = 147

19.00%

32.00%

28.00%

71.00%

77.00%

82.00%

n = 442

47.00%

81.00%

82.00%

98.00%

99.00%

100.00%

simuPOP

n = 72

26.20%

20.90%

28.80%

87.90%

59.90%

88.20%

n = 147

28.70%

20.80%

30.50%

92.40%

56.30%

91.70%

n = 442

66.80%

69.90%

78.40%

100.00%

99.70%

100.00%