Table 2 Enriched functional categories for the top 500 Sirt3 correlated genes obtained from two different datasets
From: Evaluation of Sirtuin-3 probe quality and co-expressed genes using literature cohesion
Dataset | Database_category | Term | Gene count | % of input genes | p-value | Adj p-value |
|---|---|---|---|---|---|---|
DS1: SUH BXD Liver CCl4-treated Affy Mouse Gene 1.0 ST (Jun11) RMA : 10568997 (263 Gene IDs) | ||||||
| Â | UP_KEYWORDS | Acetylation | 102 | 0.39 | 8.29E-24 | 2.11E-21 |
| Â | GOTERM_CC_DIRECT | GO:0005739 mitochondrion | 76 | 0.29 | 1.47E-21 | 4.79E-19 |
| Â | GOTERM_BP_DIRECT | GO:0055114 oxidation-reduction process | 31 | 0.12 | 1.68E-08 | 2.50E-05 |
| Â | KEGG_PATHWAY | mmu00280:Valine leucine and isoleucine degradation | 10 | 0.04 | 3.80E+00 | 3.81E-04 |
| Â | GOTERM_MF_DIRECT | GO:0000166 nucleotide binding | 49 | 0.19 | 1.80E-05 | 5.13E-03 |
|  | KEGG_PATHWAY | mmu05016:Huntington’s disease | 16 | 0.06 | 1.84E-05 | 1.81E-03 |
| Â | GOTERM_BP_DIRECT | GO:0006629 lipid metabolic process | 20 | 0.08 | 2.14E-05 | 6.37E-03 |
| Â | KEGG_PATHWAY | mmu00190:Oxidative phosphorylation | 13 | 0.05 | 3.65E-05 | 1.79E-03 |
| Â | GOTERM_BP_DIRECT | GO:0006099 tricarboxylic acid cycle | 6 | 0.02 | 4.31E-05 | 9.15E-03 |
| Â | GOTERM_CC_DIRECT | GO:0043209 myelin sheath | 12 | 0.05 | 4.69E-05 | 1.69E-03 |
| Â | GOTERM_CC_DIRECT | GO:0005925 focal adhesion | 17 | 0.06 | 6.08E-05 | 1.80E-03 |
|  | KEGG_PATHWAY | mmu05012:Parkinson’s disease | 13 | 0.05 | 7.23E-05 | 2.83E-03 |
| Â | GOTERM_BP_DIRECT | GO:0042632 cholesterol homeostasis | 7 | 0.03 | 2.26E-04 | 3.68E-02 |
|  | KEGG_PATHWAY | mmu05010:Alzheimer’s disease | 13 | 0.05 | 3.68E-04 | 1.20E-02 |
DS3: UMUTAffy Hippocampus Exon (Feb09) RMA Database (307 Gene IDs) | ||||||
| Â | UP_KEYWORDS | Acetylation | 156 | 0.51 | 1.33E-50 | 3.21E-48 |
| Â | GOTERM_CC_DIRECT | GO:0005739 mitochondrion | 85 | 0.28 | 3.49E-22 | 1.19E-19 |
| Â | GOTERM_MF_DIRECT | GO:0003735 structural constituent of ribosome | 30 | 0.10 | 4.17E-19 | 1.80E-16 |
| Â | GOTERM_BP_DIRECT | GO:0006412 translation | 36 | 0.12 | 1.76E-18 | 1.72E-15 |
|  | KEGG_PATHWAY | mmu05016:Huntington’s disease | 26 | 0.08 | 1.17E-12 | 6.36E-11 |
|  | KEGG_PATHWAY | mmu05012:Parkinson’s disease | 20 | 0.07 | 8.29E-11 | 3.01E-09 |
| Â | KEGG_PATHWAY | mmu00190:Oxidative phosphorylation | 19 | 0.06 | 3.81E-10 | 1.04E-08 |
| Â | KEGG_PATHWAY | mmu03050:Proteasome | 13 | 0.04 | 4.95E-10 | 1.08E-08 |
|  | KEGG_PATHWAY | mmu05010:Alzheimer’s disease | 20 | 0.07 | 7.75E-09 | 1.41E-07 |
| Â | KEGG_PATHWAY | mmu04932:Non-alcoholic fatty liver disease (NAFLD) | 18 | 0.06 | 5.30E-08 | 8.25E-07 |
| Â | GOTERM_BP_DIRECT | GO:0055114 oxidation-reduction process | 29 | 0.09 | 6.55E-06 | 1.29E-03 |
| Â | GOTERM_BP_DIRECT | GO:0016192 vesicle-mediated transport | 14 | 0.05 | 6.26E-05 | 1.02E-02 |
| Â | GOTERM_CC_DIRECT | GO:0043209 myelin sheath | 13 | 0.04 | 6.97E-05 | 1.48E-03 |
| Â | GOTERM_CC_DIRECT | GO:0005925 focal adhesion | 16 | 0.05 | 0.0017766 | 2.71E-02 |