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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk

Fig. 4

Determining relationships between BE/EAC genes and miR-4423. a Networks for the genes and miR-4423 in BE and EAC. Analysis of key genes using Comparative Toxicogenomics Database showed pathways similar to those identified by the MetaCore database. These pathways are affected in BE and EAC. Increased representation of a miR-4423-related (i.e., BEmiRNA in the figure) pathway inversely correlates with BE-specific pathways. Note that miR-4423 is the microRNA adjacent to WDR63. Overlap exists across BE, EAC, and miR-4423 pathways or processes. b Networks for EAC-specific genes and miR-4423. Analysis of the key genes and Comparative Toxicogenomics Database showed pathways similar to those identified by the MetaCore database that are affected by BE and EAC. Interestingly, the miR-4423-related pathway (BEmiRNA) is significantly overrepresented in cholecystokinin signaling. In general, the miR-4423 pathway is underrepresented compared to other pathways. Overlap exists across EAC and the miR-4423 pathways or processes

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BMC Bioinformatics

ISSN: 1471-2105

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