Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk

Table 2 Distribution of IRs and significant genes across cTOH regions

Chromosome	No. of IRs	Min (bp)	Max (bp)	Average (bp)	No. of genes with IRs	Significant genes^a
chr1	1362	39	14,668	4731	10	MCOLN2, *WDR63* ^b
chr2	11,340	41	11,425	5025	19
chr3	5591	39	15,570	4512	18	EOMES, *KAT2B* ^b , *RBMS3* ^b
chr4	6635	39	18,320	4451	12	TMEM165
chr6	4166	39	17,214	4220	11
chr7	4219	43	11,301	4728	24	AMZ1, *GNA12* ^b , IQCE, SDK1, SNX8, TTYH3
chr8	4440	39	21,947	4492	12	C8orf84, HNF4G, *VPS13B* ^b
chr9	10,387	39	18,110	4711	33	C9orf98, LAMC3, NUP214, RFK, RPSAP9, TMEM2, *TLE1* ^b
chr12	1754	41	20,219	4064	6	METTL1, *MON2* ^b , USP15
chr13	1008	39	13,255	3672	0
chr14	2186	39	19,438	4482	9	*CTAGE5* ^b , SEC23A, SLC25A21
chr15	3852	39	11,243	4718	14	AAGAB, IQCH, LRRC49
chr18	2711	39	13,381	4319	4	B4GALT6
chr20	2207	39	12,552	4448	8	C20orf7

^aPresent in at least three out of eight samples
^bOf the 33 genes, the pathway analysis prioritized eight genes to the NOTCH, transcription, inflammation, and signaling pathways of BE/EAC

ISSN: 1471-2105