From: FoPA: identifying perturbed signaling pathways in clinical conditions using formal methods
FoPA | PADOG | ||||||
Rank | KEGG pathway | KEGG ID | PFoPA | Rank | KEGG pathway | KEGG ID | PPADOG |
1 | Non-small cell lung cancer | 05223 | 0.0064 | 1 | RNA transport | 03013 | 0.0001 |
2 | Intestinal immune network for IgA production | 04672 | 0.0194 | 2 | Cell cycle | 04110 | 0.0001 |
3 | Aldosterone-regulated sodium reabsorption | 04960 | 0.0194 | 3 | p53 signaling pathway | 04115 | 0.0001 |
4 | Tight junction | 04530 | 0.038 | 4 | Progesterone-mediated oocyte maturation | 04914 | 0.0001 |
5 | p53 signaling pathway | 04115 | 0.048 | 5 | Colorectal cancer | 05210 | 0.0001 |
6 | Wnt signaling pathway | 04310 | 0.05 | 6 | Non-small cell lung cancer | 05223 | 0.0001 |
7 | Mineral absorption | 04978 | 0.0679 | 7 | Endometrial cancer | 05213 | 0.01 |
8 | Renin-angiotensin system | 04614 | 0.067 | 8 | Small cell lung cancer | 05222 | 0.0299 |
9 | Alzheimer’s disease | 05010 | 0.07 | 9 | Glioma | 05214 | 0.0299 |
10 | Vasopressin-regulated water reabsorption | 04962 | 0.07 | 10 | RNA degradation | 03018 | 0.040 |
11 | NF-kappa B signaling pathway | 04064 | 0.07 | 11 | Apoptosis | 04210 | 0.040 |
12 | Neurotrophin signaling pathway | 04722 | 0.08 | 12 | Prostate cancer | 05215 | 0.040 |
13 | Melanoma | 05218 | 0.09 | 13 | Prion diseases | 05020 | 0.040 |
14 | Colorectal cancer | 05210 | 0.1 | 14 | Gap junction | 04540 | 0.050 |
15 | Leukocyte transendothelial migration | 04670 | 0.12 | 15 | Pancreatic cancer | 05212 | 0.050 |
… | … | ||||||
28 | Wnt signaling pathway | 04310 | 0.2 | ||||
CePa | SPIA | ||||||
Rank | KEGG pathway | KEGG ID | PCePa | Rank | KEGG pathway | KEGG ID | PSPIA |
1 | Cell adhesion molecules (CAMs) | 04514 | 0.009 | 1 | Chemokine signaling pathway | 04062 | 0.001 |
2 | Taurine and hypotaurine metabolism | 00430 | 0.009 | 2 | Cell cycle | 04110 | 0.001 |
3 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 00563 | 0.009 | 3 | p53 signaling pathway | 04115 | 0.001 |
4 | Regulation of actin cytoskeleton | 04810 | 0.009 | 4 | ECM-receptor interaction | 04512 | 0.001 |
5 | Circadian rhythm | 04710 | 0.009 | 5 | Gap junction | 04540 | 0.001 |
6 | Neurotrophin signaling pathway | 04722 | 0.009 | 6 | Natural killer cell mediated cytotoxicity | 04650 | 0.001 |
7 | Alanine, aspartate and glutamate metabolism | 00250 | 0.009 | 7 | Fc gamma R-mediated phagocytosis | 04666 | 0.001 |
8 | Drug metabolism - other enzymes | 00983 | 0.009 | 8 | Cholinergic synapse | 04725 | 0.001 |
9 | Dilated cardiomyopathy (DCM) | 05414 | 0.009 | 9 | GABAergic synapse | 04727 | 0.001 |
10 | Wnt signaling pathway | 04310 | 0.009 | 10 | Regulation of actin cytoskeleton | 04810 | 0.001 |
11 | Fructose and mannose metabolism | 00051 | 0.009 | 11 | Aldosterone-regulated sodium reabsorption | 04960 | 0.001 |
12 | NOD-like receptor signaling pathway | 04621 | 0.009 | 12 | HTLV-I infection | 05166 | 0.001 |
13 | Autophagy – animal | 04140 | 0.009 | 13 | Prostate cancer | 05215 | 0.001 |
14 | Glycosphingolipid biosynthesis - lacto and neolacto series | 00601 | 0.009 | 14 | Systemic lupus erythematosus | 05322 | 0.001 |
15 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 05412 | 0.009 | … | 0.001 | ||
123 | Wnt signalling pathway | 04310 | 0.97 |