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Table 1 Comparison of existing open-source software tools with similar functions

From: GenESysV: a fast, intuitive and scalable genome exploration open source tool for variants generated from high-throughput sequencing projects

Features GenESysV GEMINI BrowseVCF VCF-Miner Mendel,MD BiERapp
Graphical Usera Interface Yes No Yes Yes Yes Yes
Study type Single cohort complex disease, Case/Control, and Mendelian inheritance Single cohort complex disease and Mendelian inheritance Single cohort complex and Mendelian inheritance Single cohort complex disease and Mendelian inheritance Mendelian only Single cohort complex disease, Case/Control, and Mendelian inheritance
Whole genome, exome or target study All All All All WES or targeted study WES or target study
Can handle studies with large numbers of samples Yes Yes No No No No
Database Type Elasticsearch Sqlite3 Wormtable & BerkeleyDB MongoDB PostgreSQL SQLite & MongoDB
Flag variants for further filtering Yes No No No No No
  1. aFeatures listed here are not exhaustive