Prediction of drug-disease associations based on ensemble meta paths and singular value decomposition

Wu, Guangsheng; Liu, Juan; Yue, Xiang

doi:10.1186/s12859-019-2644-5

BMC Bioinformatics

Table 4 The predicted drug-disease associations (Top 20)

From: Prediction of drug-disease associations based on ensemble meta paths and singular value decomposition

Rank	Score	DrugBank ID	Drug name	OMIM ID	Disease name	Literature validation
1	0.994	DB00776	Oxcarbazepine	239350	Hyperphosphatemia, Polyuria, And Seizures	[38]
2	0.992	DB01234	Dexamethasone	151590	Lichen Sclerosus Et Atrophicus; Lsa	[39]
3	0.991	DB00443	Betamethasone	233810	Growth Retardation, Small And Puffy Hands And Feet, And Eczema	[36]
4	0.991	DB00694	Daunorubicin	236000	Hodgkin Lymphoma	[40, 41]
5	0.987	DB01234	Dexamethasone	146850	Immune Suppression; Is	[42]
6	0.986	DB01013	Clobetasol propionate	233810	Growth Retardation, Small And Puffy Hands And Feet, And Eczema	N.A.
7	0.986	DB00620	Triamcinolone	125600	Dermatosis Papulosa Nigra	N.A.
8	0.986	DB00863	Ranitidine	600263	Helicobacter Pylori Infection, Susceptibility To	[43]
9	0.985	DB00620	Triamcinolone	233810	Growth Retardation, Small And Puffy Hands And Feet, And Eczema	[34, 35]
10	0.984	DB00694	Daunorubicin	267730	Reticulum Cell Sarcoma	[44]
11	0.984	DB00694	Daunorubicin	109543	Leukemia, Chronic Lymphocytic, Susceptibility To, 2	N.A.
12	0.984	DB00773	Etoposide	247640	Lymphoblastic Leukemia, Acute, With Lymphomatous Features; Lall	[45, 46]
13	0.984	DB00214	Torasemide	256370	Nephrotic Syndrome, Early-Onset, With Diffuse Mesangial Sclerosis	N.A.
14	0.983	DB00443	Betamethasone	188030	Thrombocytopenic Purpura, Autoimmune; Aitp	[47]
15	0.981	DB00444	Teniposide	601626	Leukemia, Acute Myeloid; Aml	[48, 49]
16	0.981	DB00481	Raloxifene	215470	Chorioretinal Dystrophy, Spinocerebellar Ataxia, And Hypogonadotropic	N.A.
17	0.980	DB00335	Atenolol	608622	Hypertension, Diastolic, Resistance To	[50]
18	0.980	DB00612	Bisoprolol	608622	Hypertension, Diastolic, Resistance To	[51]
19	0.980	DB00443	Betamethasone	146850	Immune Suppression; Is	N.A.
20	0.980	DB01177	Idarubicin	109543	Leukemia, Chronic Lymphocytic, Susceptibility To, 2	N.A.

N.A.: We haven’t found the literature evidence

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ISSN: 1471-2105

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