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Table 1 Area under the ROC curve (AUROC), showing stem/loop classification of reactivity scoring methods

From: reactIDR: evaluation of the statistical reproducibility of high-throughput structural analyses towards a robust RNA structure prediction

  icSHAPE PARS
Method in vivo in vitro V1(cont) S1(case)
Count *0.555 *0.514 * 0.702 * 0.349
Score *0.600 *0.564 *0.574  
BUMHMM *0.592 *0.526 *0.634  
PROBer 0.645 0.607 *0.639  
IDR *0.563 *0.518 * 0.664 * 0.375
reactIDR 0.665 0.626 0.715 0.420
  1. * AUROC is significantly lower than that of reactIDR with p-value<0.05 for the comparison after Bonferroni correction. AUROCs obtained by methods not originally designed for PARS experiments. Structure scores of Score, BUMHMM, and PROBer are common for the case and control conditions of the PARS dataset. Their AUROC significances were computed for that of reactIDR for the PARS V1 condition