Fig. 1

Super-enhancer domains can be grouped into distinct categories. a A definition of super-enhancer domains. b A smooth scatter plot between tau score (x-axis) and the number of cell/tissue types associated with super-enhancer domains. Vertical arrowheads indicate 20 and 80% percentile of tau score. Red, blue, and green colored box indicate unique, non-unique and common super-enhancer domains, respectively. c-e Heatmaps of background-subtracted H3K27ac RPM of super-enhancer domains across cell/tissue types. Color intensity indicates log2 transformed H3K27ac RPM of super-enhancer domains. f-h Genome browser snapshots showing H3K27ac signals of each class of super-enhancer domain examples. Unique super-enhancer domain nearby SOX1, specific to neuronal progenitor cells (f). Non-unique super-enhancer domain nearby TJP3, specific to digestive system related tissues (g). Common super-enhancer domain nearby MALAT1 and NEAT1 (h). H3K27ac signal is uniformly scaled in the range of 0–20. Cell/tissue types are grouped according to their lineage or functional similarity