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Table 2 Enrichment results in different tissues in the GTEx database

From: Identification of trans-eQTLs using mediation analysis with multiple mediators

Tissue Sample size Cis-association (FDR<0.05) Trans-association (FDR<0.1) Trans-associationa Trans-associationb Empirical p-value
Adipose subcutaneous 298 1282841 45 10 10 0.009
Adrenal gland 126 396098 1 0 0 1
Artery aorta 197 853794 288 2 243 <0.001
Artery tibial 256 1210709 12 3 1 0.156
Brain hypothalamus 81 150415 2 0 0 1
Brain nucleus accumbens (basal ganglia) 93 244929 2 0 0 1
Brain putamen (basal ganglia) 82 183240 11 0 0 1
Cells transformed fibroblasts 272 1283340 658 19 376 <0.001
Colon transverse 169 581854 18 0 6 0.006
Esophagus mucosa 241 1089061 980 122 145 <0.001
Esophagus muscularis 218 997653 15 5 10 0.001
Heart left ventricle 190 605253 3 3 0 1
Lung 278 1068860 98 0 8 0.041
Muscle skeletal 361 1100532 59 0 35 <0.001
Nerve tibial 256 1454889 30 10 1 0.288
Pancreas 149 515665 283 0 244 <0.001
Prostate 87 177994 1 0 0 1
Skin not sun-exposed (suprapubic) 196 722868 11 0 6 0.004
Skin sun-exposed (lower leg) 302 1306762 64 13 25 <0.001
Testis 157 1121727 203 34 68 0.013
Thyroid 278 1551668 2120 230 1390 <0.001
Whole blood 338 1036239 35 2 24 <0.001
  1. aTrans-association in which the trans-eQTL is also associated with 1 cis-gene
  2. bTrans-association in which the trans-eQTL is also associated with 2 or more cis-genes