From: Identification of trans-eQTLs using mediation analysis with multiple mediators
Tissue | Sample size | Cis-association (FDR<0.05) | Trans-association (FDR<0.1) | Trans-associationa | Trans-associationb | Empirical p-value |
---|---|---|---|---|---|---|
Adipose subcutaneous | 298 | 1282841 | 45 | 10 | 10 | 0.009 |
Adrenal gland | 126 | 396098 | 1 | 0 | 0 | 1 |
Artery aorta | 197 | 853794 | 288 | 2 | 243 | <0.001 |
Artery tibial | 256 | 1210709 | 12 | 3 | 1 | 0.156 |
Brain hypothalamus | 81 | 150415 | 2 | 0 | 0 | 1 |
Brain nucleus accumbens (basal ganglia) | 93 | 244929 | 2 | 0 | 0 | 1 |
Brain putamen (basal ganglia) | 82 | 183240 | 11 | 0 | 0 | 1 |
Cells transformed fibroblasts | 272 | 1283340 | 658 | 19 | 376 | <0.001 |
Colon transverse | 169 | 581854 | 18 | 0 | 6 | 0.006 |
Esophagus mucosa | 241 | 1089061 | 980 | 122 | 145 | <0.001 |
Esophagus muscularis | 218 | 997653 | 15 | 5 | 10 | 0.001 |
Heart left ventricle | 190 | 605253 | 3 | 3 | 0 | 1 |
Lung | 278 | 1068860 | 98 | 0 | 8 | 0.041 |
Muscle skeletal | 361 | 1100532 | 59 | 0 | 35 | <0.001 |
Nerve tibial | 256 | 1454889 | 30 | 10 | 1 | 0.288 |
Pancreas | 149 | 515665 | 283 | 0 | 244 | <0.001 |
Prostate | 87 | 177994 | 1 | 0 | 0 | 1 |
Skin not sun-exposed (suprapubic) | 196 | 722868 | 11 | 0 | 6 | 0.004 |
Skin sun-exposed (lower leg) | 302 | 1306762 | 64 | 13 | 25 | <0.001 |
Testis | 157 | 1121727 | 203 | 34 | 68 | 0.013 |
Thyroid | 278 | 1551668 | 2120 | 230 | 1390 | <0.001 |
Whole blood | 338 | 1036239 | 35 | 2 | 24 | <0.001 |