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Table 2 Representative enriched GO terms of the selected modules for OV dataset

From: CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer

Module

GO term

Description

q-value

Cancer lncRNAs

Cancer miRNAs

Cancer mRNAs

2

GO:0002376

immune system process

1.04E-12

MALAT1, MIR155HG, NEAT1, PVT1

mir-10a

APOC1, APOE, BTG3, C1QA, C1QB, CBS, CCL2, etc

GO:0009605

response to external stimulus

2.31E-07

GO:0006954

inflammatory response

2.76E-04

GO:0050865

regulation of cell activation

2.25E-03

GO:0007154

cell communication

2.25E-03

7

GO:0032502

developmental process

1.32E-06

DLEU2, DNM3OS, GAS5, HOTAIRM1, MALAT1, SNHG1, SNHG3, SNHG5, TP53TG1

mir-196b, mir-199b

CHST2,CLDN11,COX6B1, MGP, DACT3, DCHS1, DLK1, etc

GO:0030154

cell differentiation

1.62E-05

GO:0060284

regulation of cell development

1.06E-04

GO:0010942

positive regulation of cell death

2.89E-04

GO:0007275

multicellular organismal development

7.77E-07

15

GO:0007155

cell adhesion

2.57E-06

GAS5, H19, MEG3, SNHG5

mir-202, mir-506, mir-508, mir-513c

FSTL1, LHX1, MEST, MFAP2, CDH3, NR5A1, MMP2, etc

GO:0022610

biological adhesion

2.64E-06

GO:0009968

negative regulation of signal transduction

1.38E-03

GO:0042698

ovulation cycle

3.10E-04

GO:0050896

response to stimulus

2.54E-05

17

GO:0022411

cellular component disassembly

1.43E-20

DNM3OS, GAS5, H19, LINC00467, MEG3, RMRP, RP11-304 L19.5, RP11-385 J1.2, SNHG5

mir-127,mir-134,mir-379, mir-370,mir-382,mir-409, mir-410, mir-431, mir-432, mir-433,mir-485, mir-493, mir-654, mir-758

GPC3, SPARC, LHX1, LUM, MEST, MFAP2, IGF2BP2, etc

GO:0009968

negative regulation of signal transduction

7.65E-04

GO:0060284

regulation of cell development

8.80E-04

GO:0045595

regulation of cell differentiation

5.91E-04

GO:0006413

translational initiation

8.31E-21

  1. Note: The bold letters represent the lncRNAs/miRNAs/mRNAs related to ovarian cancer; q-value represents the corrected p-value using the Benjamini-Hochberg method