Table 3 High Scoring Pairs of Interest from TF Model
From: Predicting clinically promising therapeutic hypotheses using tensor factorization
Target | High Scoring Indication in Clinical Pipeline (Phase*) | PubmedID | Related Approved Indication (Total Approved Indications) |
|---|---|---|---|
ABCC8 | Glucose Intolerance (III) | 23903354 | Diabetes Mellitus (1) |
ADRB1 | Cachexia (II) | 20426789 | Ischemia (13) |
ADRB2 | Hypoglycemia (I) | 22013013 | Glaucoma (15) |
ADRB2 | Myocardial Infarction (III) | 26692153 | Heart Failure (15) |
AGTR1 | Hypercholesterolemia (III) | 12117739 | Hyperlipidemias (7) |
CYP3A4 | Hepatitis C (II) | 20938912 | HIV Infections (1) |
IL2 | Behcet Syndrome (II) | 26654556 | Graft Rejection (1) |
IL6 | Waldenstrom Macroglobulinemia (I) | 26238488 | Giant Lymph Node Hyperplasia (1) |
IL6 | Arthritis, Psoriatic (II) | 27789987 | Giant Lymph Node Hyperplasia (1) |
OPRM1 | Schizophrenia (III) | 27397309 | Migraine Disorders (22) |
RYR1 | Muscular Dystrophy, Duchenne (I) | 26793121 | Malignant Hyperthermia (1) |
SERPINC1 | Hemophilia (II) | 27099538 | Blood Coagulation Disorders (16) |
TNFSF11 | Hypercalcemia (II) | 27904108 | Osteoporosis (1) |
VDR | Alopecia (I) | 27932380 | Keratosis (9) |
VDR | Cachexia (I) | 22497530 | Chronic Kidney Failure (9) |