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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer

Fig. 5

A fragment of a diagram of the signal transduction network combined with the gene regulatory network predicted by MGE workflow as playing a regulatory role in CRC. Red nodes represent master-regulators identified by the network analysis algorithm. Blue nodes represent transcription factors predicted by CMA in the gene regulatory regions of the differently expressed genes (green arrows on a blue lines at the bottom). Red stars represent methylated CpG loci identified in our work whose methylation level correlates with expression level of the genes. Red arrows show translation of the genes into proteins making the multiple feedback loops in the system. The products of the differentially expressed genes play the master-regulatory role in the system. Brown and violet shading around some nodes in the network shows the level of up-regulation or down-regulation of the genes encoding these proteins

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