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Table 1 The final list of 19 TFs after filtering according to their differential expression as well as differential DNA methylation and the level of correlation with the methylation in the associated CpG loci

From: Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer

Ensembl TF gene symbol TF protein name correl logFC I_stage vs. Control logFC Cancer vs. Control Methylation logFC Cancer vs. Control CMA NEG_200bp CMA POS_200bp CMAcorrel_500bp F-Match NEG_200bp F-Match POS_200bp
ENSG00000198521 ZNF43 ZNF43 −0.763 − 0.706 − 0.711 0.296 +     
ENSG00000257591 ZNF625 ZNF625 −0.667 −0.461 − 0.365 0.558 +     
ENSG00000136997 MYC c-Myc −0.567 2.126 2.442 −0.682    +   
ENSG00000197905 TEAD4 TEF-3 −0.453 1.829 2.335 −0.589    +   +
ENSG00000139515 PDX1 IPF-1 −0.407 2.565 2.869 0.541     + +
ENSG00000125798 FOXA2 HNF-3beta −0.364 0.821 1.312 −0.332 + +    
ENSG00000177426 TGIF1 TGIF −0.282 1.003 1.511 −0.294 +     +
ENSG00000204103 MAFB MafB −0.244 −0.678 − 0.226 0.280   +    
ENSG00000149948 HMGA2 HMGI-C −0.242 0.533 1.016 −0.284   +    +
ENSG00000137309 HMGA1 HMGIY −0.220 1.422 1.758 −0.328 + +    
ENSG00000169016 E2F6 E2F-6 −0.204 0.793 1.259 −0.420 +     
ENSG00000196628 TCF4 ITF-2 −0.166 −0.429 0.021a 0.332   +    
ENSG00000159216 RUNX1 AML1 −0.057 0.911 1.525 −0.556 +     
ENSG00000075426 FOSL2 Fra-2 −0.050 −0.559 − 0.027a −0.386 +    +  
ENSG00000164749 HNF4G HNF-4gamma 0.064 −0.708 − 0.209 − 0.365 + +    
ENSG00000129514 FOXA1 HNF-3alpha 0.183 −1.296 −0.768 − 0.430 + +    
ENSG00000156127 BATF B-ATF 0.222 0.607 1.028 −0.416   +    
ENSG00000176842 IRX5 IRX2a 0.355 0.890 1.155 0.400   + + +  
ENSG00000113580 NR3C1 GR 0.548 −1.331 −0.931 − 0.588 + + +   
  1. a The LogFC was not significant for the full Cancer vs Control comparison, but was highly significant for the Cancer stage I vs Control